Multiple neurofibrosarcoma in a patient with Neurofibromatosis-1 : a case report

Neurofibromatosis-1 is a multi-systemic; genetic and progressive disease. The patients have an increased risk of malignant transformation. Neurofibrosarcoma is rare but when it occurs; may pursue an aggressive course. This case report is of a 30-year-old female patient who first presented at the University of Calabar Teaching Hospital in November 2004 with a neurofibrosarcoma of the right foot complicating a neurofibroma of the same foot first noticed 27 years earlier. She had a right below knee amputation. Fourteen months later she presented with a huge tumour involving the right lower and middle lobes for which a right lower and middle lobectomy was done. The histology of the specimen confirmed neurofibrosarcoma. In the developing world late presentation is common with increased risk of malignant transformation. Early diagnosis and follow-up; genetic coun- selling of patients and relations on early presentation would improve outcome

Angiomyolipoma : a report of two cases

Objective: We report two cases of unusual renal tumours in two Nigerian adults. The first case was in a 45 year old female; who presented with an insidious onset of right upper abdominal pain with right abdominal swelling. The second case was a 33 year old pregnant lady; presenting with three week history of right lumbar pain and an accompanying mass. The various modes of radiological investigations and their significance in making a prompt diagnosis are highlighted. Method: Abdominal ultrasound scan; intravenous urography and CT scan confirmed the presence of renal masses in both cases and the suspicion of renal malignancies were raised clinically. They both had nephrectomy. Results : Histology report of the masses revealed angiomyolipoma (AML). Conclusions: In a period of three years; out of twenty four solid renal tumours operated upon in the Lagos State University Teaching Hospital (LASUTH); two were unusual. All the others were renal cell carcinoma. All diagnosis were confirmed histologically